CHEMOATTRACTANT-INDUCED MEMBRANE HYPERPOLARIZATION IN DICTYOSTELIUM-DISCOIDEUM - A POSSIBLE ROLE FOR CYCLIC-GMP

被引：9
|
作者：
VANDUIJN, B [1 ]
MEI, W [1 ]
机构：
[1] LEIDEN UNIV,ZOOL LAB,CELL BIOL & GENET UNIT,2311 GP LEIDEN,NETHERLANDS
来源：
FEBS LETTERS | 1990年 / 275卷 / 1-2期
关键词：
Chemotaxis; Cyclic AMP; Cyclic GMP; Dictyostelium discoideum; H[!sup]+[!/sup] -ATPase; K[!sup]+[!/sup] channel;
D O I：
10.1016/0014-5793(90)81471-Y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Membrane potentials of the cellular slime mold Dictyostelium discoideum were monitored after chemotactic stimulation by measuring the distribution of the lipophilic cation tetraphenylphosphonium. Stimulation with the chemoattractant cAMP induces a transient membrane hyperpolarization which reaches its most negative value between 1 3 min after stimulation. This hyperpolarization is consistent with the opening of potassium channels. Measurements in streamer F mutant cells reveal that cGMP likely plays a role in the regulation of the cAMP-induced hyperpolarization. © 1990.
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页码：201 / 204
页数：4
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