Comorbidities of sleep disordered breathing in children;
Cognitive deficits;
Metabolic syndrome;
Growth disorders;
Cardiovascular complications;
D O I:
10.1016/S0001-6519(10)71242-5
中图分类号:
R76 [耳鼻咽喉科学];
学科分类号:
100213 ;
摘要:
Sleep-related respiratory disorders in children, especially childhood sleep apnea-hypopnea syndrome, are associated with a wide range of comorbidities affecting the central nervous system, cardiovascular and metabolic systems, and growth. The two most important factors contributing to the physiopathology of this disorder are intermittent hypoxia and sleep fragmentation, which seem to cause the systemic inflammatory response resulting in these end-organ consequences. (C) 2010 Elsevier Espana, S.L. All rights reserved.
机构:
Massachusetts Gen Hosp Children, Div Pediat Pulmonol & Sleep Med, Dept Pediat, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USAMassachusetts Gen Hosp Children, Div Pediat Pulmonol & Sleep Med, Dept Pediat, Boston, MA 02114 USA
Gipson, Kevin
Lu, Mengdi
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机构:
Massachusetts Gen Hosp Children, Div Pediat Pulmonol & Sleep Med, Dept Pediat, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USAMassachusetts Gen Hosp Children, Div Pediat Pulmonol & Sleep Med, Dept Pediat, Boston, MA 02114 USA
Lu, Mengdi
Kinane, T. Bernard
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机构:
Massachusetts Gen Hosp Children, Div Pediat Pulmonol & Sleep Med, Dept Pediat, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USAMassachusetts Gen Hosp Children, Div Pediat Pulmonol & Sleep Med, Dept Pediat, Boston, MA 02114 USA
机构:
Hop Necker Enfants Malad, Serv Genet Med, AP HP, Paris, FranceUniv Paris 06, AP HP, Hop Armand Trousseau, INSERM,Serv Pneumol Pediat,UMR S 893,Equipe 12, F-75012 Paris, France
Cohen-Gogo, S.
Thanh, C. Do Ngoc
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机构:
Hop Armand Trousseau, AP HP, Serv Neurol Pediat, Paris, FranceUniv Paris 06, AP HP, Hop Armand Trousseau, INSERM,Serv Pneumol Pediat,UMR S 893,Equipe 12, F-75012 Paris, France
Thanh, C. Do Ngoc
Levy, D.
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机构:
Hop Armand Trousseau, AP HP, Serv Hematol Oncol Pediat, Paris, FranceUniv Paris 06, AP HP, Hop Armand Trousseau, INSERM,Serv Pneumol Pediat,UMR S 893,Equipe 12, F-75012 Paris, France
Levy, D.
Metreau, J.
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机构:
Hop Bicetre, AP HP, Serv Hepatol Pediat, Le Kremlin Bicetre, FranceUniv Paris 06, AP HP, Hop Armand Trousseau, INSERM,Serv Pneumol Pediat,UMR S 893,Equipe 12, F-75012 Paris, France
Metreau, J.
Mornand, P.
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机构:
Hop Bicetre, AP HP, Serv Reanimat Pediat Polyvalente, Le Kremlin Bicetre, FranceUniv Paris 06, AP HP, Hop Armand Trousseau, INSERM,Serv Pneumol Pediat,UMR S 893,Equipe 12, F-75012 Paris, France
Mornand, P.
Parisot, P.
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机构:
Hop Necker Enfants Malad, AP HP, Serv Cardiol Pediat, Paris, FranceUniv Paris 06, AP HP, Hop Armand Trousseau, INSERM,Serv Pneumol Pediat,UMR S 893,Equipe 12, F-75012 Paris, France
机构:
Hadassah Med Ctr, Neonatal Pulmonol Serv, Pediat Pulm & Sleep Unit, IL-911111 Jerusalem, Israel
Hadassah Med Ctr, Pediat Div, IL-911111 Jerusalem, Israel
Hebrew Univ Jerusalem, Fac Med, IL-911111 Jerusalem, Israel
Hadassah Med Ctr, Wohl Translat Res Inst, IL-911111 Jerusalem, IsraelHadassah Med Ctr, Neonatal Pulmonol Serv, Pediat Pulm & Sleep Unit, IL-911111 Jerusalem, Israel
Gileles-Hillel, Alex
Bhattacharjee, Rakesh
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机构:
Univ Calif San Diego, Dept Pediat, Div Resp Med, Rady Childrens Hosp, San Diego, CA 92123 USAHadassah Med Ctr, Neonatal Pulmonol Serv, Pediat Pulm & Sleep Unit, IL-911111 Jerusalem, Israel
Bhattacharjee, Rakesh
Gorelik, Michael
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h-index: 0
机构:
Med Coll Wisconsin, Childrens Hosp Wisconsin, Div Pediat Otolaryngol, Milwaukee, WI 53226 USAHadassah Med Ctr, Neonatal Pulmonol Serv, Pediat Pulm & Sleep Unit, IL-911111 Jerusalem, Israel
Gorelik, Michael
Narang, Indra
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h-index: 0
机构:
Hosp Sick Children, Res Inst, Dept Paediat, Div Resp Med,Translat Med,Fac Dev and EDI, 51 Banff Rd, Toronto, ON M4S2V6, Canada
Univ Toronto, Dept Paediat, 51 Banff Rd, Toronto, ON M4S2V6, CanadaHadassah Med Ctr, Neonatal Pulmonol Serv, Pediat Pulm & Sleep Unit, IL-911111 Jerusalem, Israel