Mouse models for studying prostate cancer bone metastasis

被引：32
|
作者：
Dai, Jinlu [1 ]
Hensel, Janine [2 ]
Wang, Ning [3 ]
Kruithof-de Julio, Marianna [4 ]
Shiozawa, Yusuke [5 ,6 ]
机构：
[1] Univ Michigan, Dept Urol, Ann Arbor, MI 48109 USA
[2] Univ Bern, Dept Clin Res, Urol Res Lab, Bern, Switzerland
[3] Univ Sheffield, Dept Human Metab, Mellanby Ctr Bone Res, Sheffield, S Yorkshire, England
[4] Leiden Univ, Med Ctr, Dept Urol, Leiden, Netherlands
[5] Wake Forest Univ, Bowman Gray Sch Med, Dept Canc Biol, 1 Med Ctr Blvd, Winston Salem, NC 27157 USA
[6] Wake Forest Univ, Bowman Gray Sch Med, Ctr Comprehens Canc, 1 Med Ctr Blvd, Winston Salem, NC 27157 USA
来源：
BONEKEY REPORTS | 2016年 / 5卷
基金：
英国惠康基金;
关键词：
D O I：
10.1038/bonekey.2016.4
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
Once tumor cells metastasize to the bone, the prognosis for prostate cancer patients is generally very poor. The mechanisms involved in bone metastasis, however, remain elusive, because of lack of relevant animal models. In this manuscript, we describe step-by-step protocols for the xenograft mouse models that are currently used for studying prostate cancer bone metastasis. The different routes of tumor inoculation (intraosseous, intracardiac, intravenous and orthotopic) presented are useful for exploring the biology of bone metastasis.
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页数：10
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