CHROMOSOMAL-ANOMALIES AND DISTURBANCE OF TRANSCRIPTIONAL ACTIVITY AT THE PACHYTENE STAGE OF MEIOSIS - RELATIONSHIP TO MALE-STERILITY

被引：32

作者：

JAAFAR, H ^{[1
]}

GABRIELROBEZ, O ^{[1
]}

RUMPLER, Y ^{[1
]}

机构：

[1] UNIV STRASBOURG 1,FAC MED,INST EMBRYOL,11 RUE HUMANN,F-67085 STRASBOURG,FRANCE

来源：

CYTOGENETICS AND CELL GENETICS | 1993年 / 64卷 / 3-4期

关键词：

D O I：

10.1159/000133592

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Morphological analysis of pachytene spermatocytes obtained from male mice carrying three chromosomal rearrangements - a Robertsonian translocation. Rb(X-2)2Ad; an autosomal reciprocal translocation, T(16;17)43H; and a tertiary trisomic. Ts(113)70H - demonstrated frequent association between the XY bivalent and the T43H and T70H translocation chromosomes. Quantitative autoradiographic data revealed that the normal transcriptional inactivity of the XY bivalent was not significantly disturbed, in contrast to that of the 16;17 quadrivalent and the extra 1(13) marker chromosome. These results are interpreted as an extension of the XY inactivation process to the associated autosomes and discussed in relation to male sterility.

引用

页码：273 / 280

页数：8