INFLUENCE OF AGE AND COMEDICATION ON STEADY-STATE CARBAMAZEPINE SERUM LEVEL DOSE RATIOS IN JAPANESE PEDIATRIC-PATIENTS

被引：12
|
作者：
YUKAWA, E
SUZUKI, A
HIGUCHI, S
AOYAMA, T
机构：
[1] Department of Hospital Pharmacy, Kyushu University Hospital Faculty of Medicine, Kyushu University, Fukuoka, 812, Higashi-Ku Maidashi
来源：
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS | 1992年 / 17卷 / 01期
关键词：
D O I：
10.1111/j.1365-2710.1992.tb01268.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of age and co-medication on steady-state carbamazepine (CBZ) level-dose (L/D) ratios were evaluated retrospectively in 370 paediatric patients. The CBZ L/D ratio increased significantly with age up to 15 years in patients on monotherapy (L/D = 0.051 x AGE + 0.334, n = 111, r = 0.593, P < 0.001). Associated anti-epileptic therapy affected the CBZ L/D ratio, which was significantly reduced in patients on polytherapy as compared to patients on monotherapy. The study therefore suggests that routine monitoring of CBZ serum levels is extremely useful, especially in the paediatric age group, and in patients who require associated anti-epileptic medication.
引用
收藏
页码：65 / 69
页数：5
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