FK-506 PREVENTS DIABETES IN DIABETES-PRONE BB WOR RATS

被引：13
|
作者：
NICOLETTI, F
MERONI, PL
BARCELLINI, W
GRASSO, S
BORGHI, MO
LUNETTA, M
DIMARCO, R
STEFANI, S
MUGHINI, L
机构：
[1] UNIV CATANIA,DEPT MED PATHOL & METAB DIS 2,I-95124 CATANIA,ITALY
[2] UNIV MILAN,INST INTERNAL MED INFECT DIS & IMMUNOPATHOL,I-20122 MILAN,ITALY
[3] UNIV CATANIA,DEPT PATHOL,I-95124 CATANIA,ITALY
[4] UNIV CATANIA,INST MICROBIOL,I-95124 CATANIA,ITALY
来源：
INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY | 1991年 / 13卷 / 07期
关键词：
D O I：
10.1016/0192-0561(91)90057-E
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The effect of the immunosuppressant FK-506 on the development of diabetes in BB/Wor rats was investigated. Using a treatment schedule (25-mu-g i.m. from day 27 to 120), not associated with detectable general ill effects, this drug was found to completely inhibit the appearance hyperglycemia and to reduce the histological signs of pancreatic insulitis. The treatment was also able to reduce the percentages of Ia + T-lymphocytes and to block the appearance of detectable serum levels of gamma interferon (IFN).
引用
收藏
页码：1027 / 1030
页数：4
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