GLUTATHIONE-REDUCTASE FUNCTIONS AS VANADATE (V) REDUCTASE

被引：27
|
作者：
SHI, XL [1 ]
DALAL, NS [1 ]
机构：
[1] W VIRGINIA UNIV,DEPT CHEM,MORGANTOWN,WV 26505
来源：
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1990年 / 278卷 / 01期
关键词：
D O I：
10.1016/0003-9861(90)90262-W
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The oxidation of NADPH by vanadate(V) in the presence of glutathione reductase showed typical enzymatic kinetics. The oxidation was inhibited by N-ethylmaleimide, a glutathione reductase inhibitor. Superoxide dismutase had no significant effect on the oxidation, indicating noninvolvment of the superoxide radical. The vanadate(V) reduction was found to be a one-electron transfer process. These results suggest a new pathway for vanadate(V) metabolism and a new function of glutathione reductase. © 1990.
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收藏
页码：288 / 290
页数：3
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