ATTACHMENT OF HELICOBACTER-PYLORI TO HUMAN GASTRIC EPITHELIUM MEDIATED BY BLOOD-GROUP ANTIGENS

被引：949
|
作者：
BOREN, T
FALK, P
ROTH, KA
LARSON, G
NORMARK, S
机构：
[1] WASHINGTON UNIV, SCH MED, DEPT MOLEC BIOL & PHARMACOL, ST LOUIS, MO 63110 USA
[2] WASHINGTON UNIV, SCH MED, DEPT PATHOL, ST LOUIS, MO 63110 USA
[3] GOTHENBURG UNIV, SAHLGRENS HOSP, DEPT CLIN CHEM, S-41345 GOTHENBURG, SWEDEN
[4] WASHINGTON UNIV, SCH MED, DEPT MOLEC BIOL, ST LOUIS, MO 63110 USA
[5] WASHINGTON UNIV, SCH MED, DEPT PHARMACOL, ST LOUIS, MO 63110 USA
来源：
SCIENCE | 1993年 / 262卷 / 5141期
关键词：
D O I：
10.1126/science.8018146
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Helicobacter pylori is associated with development of gastritis, gastric ulcers, and adenocarcinomas in humans. The Lewis(b) (Le(b)) blood group antigen mediates H. pylori attachment to human gastric mucosa. Soluble glycoproteins presenting the Le(b) antigen or antibodies to the Le(b) antigen inhibited bacterial binding. Gastric tissue lacking Le(b) expression did not bind H. pylori. Bacteria did not bind to Le(b) antigen substituted with a terminal GalNAcalpha1-3 residue (blood group A determinant), suggesting that the availability of H. pylori receptors might be reduced in individuals of blood group A and B phenotypes, as compared with blood group O individuals.
引用
收藏
页码：1892 / 1895
页数：4
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