New oral anticoagulants in the treatment of deep venous

The treatment of deep venous thrombosis (DVT) may change with the appearance of the new antithrombotics. There is currently a clear commitment to oral anticoagulant administration, starting early activity and a specific and direct anti-xa or anti-iia target. We already have the results of two phase iii clinical trials on the treatment of DVT: RE-COVER (dabigatran) and EINSTEIN-DVT/ EXT (rivaroxaban). At the same time there are another two very advanced trials (AMPLIFY [apixaban] and HOKUSAI [edoxaban]), that have not yet published their results. In the light of the available data, it can be concluded that the new oral anticoagulants are attractive for several reasons and that research supports the idea that they could replace conventional anticoagulants (low molecular weight heparins, anti-vitamin K) in the treatment of DVT. Despite these promising results, each patient sub-group (oncological, obese, etc.) will require new studies. (C) 2011 SEACV. Published by Elsevier Espana, S.L. All rights reserved.