FAILURE OF COPPER INCORPORATION INTO CERULOPLASMIN IN THE GOLGI-APPARATUS OF LEC RAT HEPATOCYTES

被引：52
|
作者：
MURATA, Y
YAMAKAWA, E
IIZUKA, T
KODAMA, H
ABE, T
SEKI, Y
KODAMA, M
机构：
[1] TEIKYO UNIV,SCH MED,DEPT PEDIAT,TOKYO 173,JAPAN
[2] KITASATO UNIV,SCH MED,DEPT HLTH ADM,TOKYO,JAPAN
[3] KITASATO UNIV,SCH FISHERIES SCI,MARINE BIOL CHEM LAB,TOKYO,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 209卷 / 01期
关键词：
D O I：
10.1006/bbrc.1995.1510
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Copper incorporation into ceruloplasmin during ceruloplasmin synthesis was studied by comparing LEC and control rats. Major 132 and 136 kDa ceruloplasmins were found in microsomes and the Golgi apparatus, respectively, isolated from liver homogenates of LEC and control rats. Copper analysis showed that no copper was detected in the ceruloplasmin in the microsomes of either rat. Copper was present in ceruloplasmin in the Golgi apparatus and serum of controls, while it was not detected in ceruloplasmin in the Golgi apparatus and serum of the LEC rat. These results indicate that copper is incorporated into ceruloplasmin in the Golgi apparatus of normal hepatocytes. LEC rats fail to incorporate copper into ceruloplasmin in the Golgi apparatus. (C) 1995 Academic Press, Inc.
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页码：349 / 355
页数：7
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