MYELIN BASIC-PROTEIN GENE POLYMORPHISM IS NOT ASSOCIATED WITH CHRONIC PROGRESSIVE MULTIPLE-SCLEROSIS

被引：19
|
作者：
VANDEVYVER, C
STINISSEN, P
CASSIMAN, JJ
RAUS, J
机构：
[1] LIMBURGS UNIV CENTRUM,DEPT PHYSIOL,DIEPENBEEK,BELGIUM
[2] KATHOLIEKE UNIV LEUVEN,CENTRUM MENSELIJKE ERFELIJKHEID,B-3001 LOUVAIN,BELGIUM
来源：
JOURNAL OF NEUROIMMUNOLOGY | 1994年 / 52卷 / 01期
关键词：
MULTIPLE SCLEROSIS; SUSCEPTIBILITY; MYELIN BASIC PROTEIN;
D O I：
10.1016/0165-5728(94)90167-8
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In the present study a tetranucleotide (TGGA)n repeat polymorphism 5' to the myelin basic protein (MBP) gene was evaluated in a group of HLA-class II-typed, chronic progressive multiple sclerosis (MS) patients. This polymorphism has been reported by others to be associated with MS. Contrary to these reports we observed similar allele frequencies in patients and controls. Our results indicate that there is no association between MS and a polymorphism 5' to the MBP gene.
引用
收藏
页码：97 / 99
页数：3
相关论文
共 50 条
  • [1] IS MULTIPLE-SCLEROSIS ASSOCIATED WITH MYELIN BASIC-PROTEIN
    DREYFUS, JC
    [J]. M S-MEDECINE SCIENCES, 1992, 8 (10): : 1114 - 1114
  • [2] DNA LENGTH POLYMORPHISM-5' TO THE MYELIN BASIC-PROTEIN GENE IS ASSOCIATED WITH MULTIPLE-SCLEROSIS
    BOYLAN, KB
    TAKAHASHI, N
    PATY, DW
    SADOVNICK, AD
    DIAMOND, M
    HOOD, LE
    PRUSINER, SB
    [J]. ANNALS OF NEUROLOGY, 1990, 27 (03) : 291 - 297
  • [3] MYELIN BASIC-PROTEIN AND MULTIPLE-SCLEROSIS
    WHITAKER, JN
    [J]. ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES, 1983, 4 (02): : 153 - 157
  • [4] MYELIN BASIC-PROTEIN AND MULTIPLE-SCLEROSIS
    COOK, SD
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 1995, 133 (1-2) : 1 - 2
  • [5] MYELIN BASIC-PROTEIN AND MULTIPLE-SCLEROSIS
    WHITAKER, JN
    [J]. ACTA NEUROLOGICA SCANDINAVICA, 1988, 77 (03): : 245 - 246
  • [6] GENETIC SUSCEPTIBILITY TO MULTIPLE-SCLEROSIS MAY BE LINKED TO POLYMORPHISM OF THE MYELIN BASIC-PROTEIN GENE
    IBSEN, SN
    CLAUSEN, J
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 1995, 131 (01) : 96 - 98
  • [7] CSF MYELIN BASIC-PROTEIN IN MULTIPLE-SCLEROSIS
    THOMPSON, AJ
    BRAZIL, J
    MARTIN, EA
    FEIGHERY, C
    HUTCHINSON, M
    [J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1986, 49 (06): : 729 - 730
  • [8] ANTIBODIES TO MYELIN BASIC-PROTEIN IN MULTIPLE-SCLEROSIS
    HERBRINK, P
    VANLAMBALGEN, R
    SANDERS, EACM
    [J]. NEUROLOGY, 1985, 35 (01) : 139 - 140
  • [9] CSF MYELIN BASIC-PROTEIN IN MULTIPLE-SCLEROSIS
    THOMSON, AJ
    BRAZIL, J
    FEIGHERY, C
    WHELAN, A
    KELLET, J
    MARTIN, EA
    HUTCHINSON, M
    [J]. ACTA NEUROLOGICA SCANDINAVICA, 1985, 72 (06): : 577 - 583
  • [10] RADIOIMMUNOASSAY OF MYELIN BASIC-PROTEIN IN MULTIPLE-SCLEROSIS
    BRAZIL, JK
    THOMPSON, AJ
    WHELAN, CA
    HUTCHINSON, M
    FEIGHERY, C
    MARTIN, EA
    [J]. IRISH JOURNAL OF MEDICAL SCIENCE, 1984, 153 (11) : 412 - 412
12345