PANCREATICO DUODENAL NEUROENDOCRINE TUMOURS - OUR EXPERIENCE OVER THE PAST 2 YEARS

INTRODUCTION: Pancreaticoduodenal Neuroendocrine tumours are a heterogeneous group of tumours with their origin in neuroendocrine cells of the embryological gut which are positive for 'Pan-neuroendocrine' markers including chromogranin A and synaptophysin. The estimated incidence is 5.25/100,000/year. They appear at all ages with the highest incidence from the 5th decade onwards. This article presents a review of our experience with pancreaticoduodenal neuroendocrine tumours over the past 2 years (2012 to 2014). Description of Cases: Over a period of 2 years from 2012 to 2014 we came across 5 cases of pancreaticoduodenal neuroendocrine tumours with age group ranging from 38 to 70 years. Of the 5 patients 3 cases (60%) were males and the remaining 2 cases were females (40%). 4 out of 5 patients underwent Whipples procedure. 1 case was stage 4 disease at presentation and inoperable. DISCUSSION: Pancreaticoduodenal NET present with varying signs and symptoms. Routine workup includes USG, CECT, USG / CT guided FNAC-tissue diagnosis, Somatostatin Receptor Scintigraphy, EUS - Most sensitive for small tumours, Serum tumor markers: Cg A; NSE. Surgery is the primary modality of treatment. The goal of surgery is local disease control. CONCLUSION: All patients are to be considered potential candidates for curative surgery especially duodenal NET. Curative resection of the primary tumour and loco regional lymph node metastases improves outcomes in these patients.