Prevalence and Antibiotic Susceptibility Pattern of Methicillin Resistant Staphylococcus aureus in Diabetic foot Ulcer

Diabetic foot ulcer(DFU) is the most common complication in diabetic patients, infection has led to increased mortality and sometimes may lead to amputation of limb. Staphylococcus aureus is the most common organism causing infection in DFU, and there is high prevalence of Methicillin-resistant Staphylococcus aureus (MRSA) among them. MRSA is a virulent organism causing delayed wound healing and mortality. To determine the prevalence of Methicillin resistant Staphylococcus aureus in diabetic foot ulcer and to determine antimicrobial susceptibility pattern among MRSA strains. A prospective study pus samples / wound swab were cultured from 100 patients who attented out patients and in patients at diabetic foot clinic with diabetic foot ulcer. Specimens were subjected to routine microbiological study, and antibiotic susceptibility was done by Kirby-Baurer disk diffusion test. Out of 100 wound samples 143organisms were isolated, of which 31(21.67%) were staphylococcus aureus. These isolates were tested for Methicillin susceptibility and was found that 13 (41.93%) were resistant and 18(57.8%) were susceptible. These MRSA strains showed high resistance to Ampicillin (100%), Penicillin (100%), tetracycline (70.3%), Amoxycillin (69.23%), and MRSA isolates were sensitive to Vancomycin (100%), Linezolid (100%) Erthromycin (66%) and Amoxycillin/clavulanic acid (69.3%). There is high prevalence of MRSA among diabetic foot ulcers.