Evaluation of antiangiogenic efficacy in advanced hepatocellular carcinoma: Biomarkers and functional imaging

被引：8
|
作者：
Bouattour, Mohamed [1 ]
Payance, Audrey [1 ]
Wassermann, Johanna [2 ]
机构：
[1] Paris 7 Diderot, Beaujon Univ Hosp, AP HP, Dept Hepatol, 100 Blvd Gen Leclerc, F-92110 Clichy, France
[2] Paris 6 Pierre & Marie Curie, La Pitie Salpetriere Univ Hosp, AP HP, Dept Med Oncol, F-75013 Paris, France
来源：
WORLD JOURNAL OF HEPATOLOGY | 2015年 / 7卷 / 20期
关键词：
Hepatocellular carcinoma; Antiangiogenic therapies; Sorafenib; Predictive biomarkers; Prognosis biomarkers; Functional imaging;
D O I：
10.4254/wjh.v7.i20.2245
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Many years after therapeutic wilderness, sorafenib finally showed a clinical benefit in patients with advanced hepatocellular carcinoma. After the primary general enthusiasm worldwide, some disappointments emerged particularly since no new treatment could exceed or at least match sorafenib in this setting. Without these new drugs, research focused on optimizing care of patients treated with sorafenib. One challenging research approach deals with identifying prognostic and predictive biomarkers of sorafenib in this population. The task still seems difficult; however appropriate investigations could resolve this dilemma, as observed for some malignancies where other drugs were used.
引用
收藏
页码：2245 / 2263
页数：19
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