KINETIC-STUDY OF THE ACID-CATALYZED HYDROLYSIS OF 4-METHOXYBENZOHYDROXAMIC ACID

The kinetics of the hydrolysis of the title compound have been investigated in hydrochloric, sulfuric and perchloric acids at 55-degrees-C in 10% (v/v) DMSO media. Rate maxima are observed for hydrolysis in each acid. Activation parameters have also been determined. On the basis of Yates-McClelland r hydration, Bunnett-Olsen LFER, and Cox-Yates excess acidity treatments, the mechanism is seen as involving a pre-equilibrium protonation followed by a rate-limiting A-2 type nucleophilic attack by water.