SITE-SELECTIVE HYDROXYLATION OF STEROIDS VIA OXOMETALLOPORPHINATES COVALENTLY LINKED TO RING-D - INTRODUCTION OF HYDROXYL-GROUPS INTO THE C(9) AND C(12) POSITION OF 5-ALPHA-ANDROSTANES

被引：32

作者：

STUK, TL ^{[1
]}

GRIECO, PA ^{[1
]}

MARSH, MM ^{[1
]}

机构：

[1] INDIANA UNIV,DEPT CHEM,BLOOMINGTON,IN 47405

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1991年 / 56卷 / 09期

关键词：

D O I：

10.1021/jo00009a006

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oxidation of synthetic manganese(III) porphyrins attached to steroidal substrates at C(17) (cf. 2 and 3) gives rise to hydrogen atom abstraction at C(9) and/or C(12), thereby leading to hydroxyl incorporation at these sites. The use of more robust metalloporphyrins (cf. 9) results in substantial increases in the yields of hydroxylated 5-alpha-androstanes.

引用

页码：2957 / 2959

页数：3