GENETICS OF A MULTIFACTORIAL DISEASE - AUTOIMMUNE TYPE-I DIABETES-MELLITUS

被引：2
|
作者：
CORNALL, RJ
机构：
[1] Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington
来源：
CLINICAL SCIENCE | 1993年 / 84卷 / 03期
基金：
英国惠康基金;
关键词：
DIABETES; MICROSATELLITES; NONOBESE DIABETIC MOUSE;
D O I：
10.1042/cs0840257
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
1. Three non-major histocompatability complex genes, Idd-3, Idd-4 and Idd-5, that influence the onset of autoimmune type 1 diabetes in the non-obese diabetic mouse have been located on chromosomes 3, 11 and 1. 2. In undertaking this study, a new map of the mouse genome has been created from polymerase chain reaction-analysable mouse microsatellite markers. 3. The homologues of these genes may reside on human chromosomes 1 or 4 (Idd-3), 17 (Idd-4) and 2q (Idd-5).
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页码：257 / 262
页数：6
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