PROTECTIVE EFFECT OF CISAPRIDE AGAINST INDOMETHACIN-INDUCED OBSTRUCTION OF THE GASTRIC-MUCOSAL HEMODYNAMICS IN RATS

被引：2
|
作者：
YOKOYAMA, T [1 ]
KITAZAWA, T [1 ]
ISHII, A [1 ]
OGIHARA, T [1 ]
SATO, N [1 ]
KARASAWA, A [1 ]
机构：
[1] JUNTENDO UNIV, SCH MED, DEPT GASTROENTEROL, BUNKYO KU, TOKYO 113, JAPAN
来源：
JAPANESE JOURNAL OF PHARMACOLOGY | 1994年 / 65卷 / 02期
关键词：
CISAPRIDE; STOMACH; MUCOSAL BLOOD FLOW;
D O I：
10.1254/jjp.65.171
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We investigated the effect of cisapride, a gastroprokinetic agent, on the obstructed gastric mucosal hemodynamics induced by indomethacin using an organ reflectance spectrophotometry system in rats. Indomethacin (10 mg/kg, i.v.) reduced both the gastric mucosal blood volume and the gastric mucosal blood oxygenation. Pretreatment with cisapride (0.1 mg/kg, i.v.) prevented these deteriorations. The presently-clarified gastric mucosal protective effect of cisapride may contribute to its therapeutic efficacy.
引用
收藏
页码：171 / 173
页数：3
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