INHIBITORS OF LIPOPOLYSACCHARIDE BIOSYNTHESIS IMPAIR THE VIRULENCE POTENTIAL OF ESCHERICHIA-COLI

被引：7
|
作者：
HAMMOND, SM
机构：
[1] Department of Microbiology, Glaxo SpA, Verona
来源：
FEMS MICROBIOLOGY LETTERS | 1992年 / 100卷 / 1-3期
关键词：
VIRULENCE; LIPOPOLYSACCHARIDE INHIBITOR; KDO ANALOG; ESCHERICHIA-COLI;
D O I：
10.1016/0378-1097(92)90224-C
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Inhibition of 3-deoxy-manno-octulosonate cytidylytransferase (CMP-KDO transferase; EC 2.7.7.38) by 8-amino-2,6-anhydro-3,8-dideoxy-D-glycero-D-talo-octonic acid (NH2dKDO) halts the growth of Gram-negative bacteria by depriving the cells of the 3-deoxy-D-manno-2-octulosonate required for the biosynthesis of the core region of the lipopolysaccharide components of the outer membrane. Low levels of this inhibitor increase the vulnerability of Escherichia coli to hydrophobic antibiotics, detergents, the complement-mediated antibacterial activity of serum, phagocytosis, and enhance the rate at which bacteria are cleared from the mouse bloodstream.
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页码：293 / 297
页数：5
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