POLYTHEONAMIDES, UNPRECEDENTED HIGHLY CYTOTOXIC POLYPEPTIDES, FROM THE MARINE SPONGE THEONELLA-SWINHOEI .1. ISOLATION AND COMPONENT AMINO-ACIDS

被引：57

作者：

HAMADA, T ^{[1
]}

SUGAWARA, T ^{[1
]}

MATSUNAGA, S ^{[1
]}

FUSETANI, N ^{[1
]}

机构：

[1] UNIV TOKYO, FAC AGR, MARINE BIOCHEM LAB, TOKYO 113, JAPAN

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 05期

关键词：

D O I：

10.1016/S0040-4039(00)75799-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Highly cytotoxic polypeptides, polytheonamides A-C, have been isolated from the marine sponge Theonella swinhoei. Interpretation of the 2D NMR data of the acid hydrolyzate of polytheonamide B as well as amino acid analysis led to identification of Ala, Asp, Thr, aThr, Ser, Glu, Val, Gly, Ile, t-Leu,beta-methylGlu,beta-methyille,beta-hydroxyVal, and beta-hydroxyAsp. 2D NMR data of polytheonamide B suggested the presence of gamma-hydroxy-t-leu, which was a new amino acid.

引用

页码：719 / 720

页数：2

共 9 条

[1] Polytheonamides A and B, highly cytotoxic, linear polypeptides with unprecedented structural features, from the marine sponge, Theonella swinhoei
Hamada, Toshiyuki
Matsunaga, Shigeki
Yano, Gen
Fusetani, Nobuhiro
Journal of the American Chemical Society, 2005, 127 (01): : 110 - 118
[2] BIOACTIVE MARINE METABOLISM .56. POLYTHEONAMIDES, UNPRECEDENTED HIGHLY CYTOTOXIC POLYPEPTIDES FROM THE MARINE SPONGE THEONELLA-SWINHOEI .2. STRUCTURE ELUCIDATION
HAMADA, T
SUGAWARA, T
MATSUNAGA, S
FUSETANI, N
TETRAHEDRON LETTERS, 1994, 35 (04) : 609 - 612
[3] Polytheonamides A and B, highly cytotoxic, linear polypeptides with unprecedented structural features, from the marine sponge, Theonella swinhoeiii
Hamada, T
Matsunaga, S
Yano, G
Fusetani, N
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (01) : 110 - 118
[4] ABSOLUTE STEREOSTRUCTURE OF SWINHOLIDE-A, A POTENT CYTOTOXIC MACROLIDE FROM THE OKINAWAN MARINE SPONGE THEONELLA-SWINHOEI
KITAGAWA, I
KOBAYASHI, M
KATORI, T
YAMASHITA, M
TANAKA, J
DOI, M
ISHIDA, T
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (09) : 3710 - 3712
[5] MARINE NATURAL-PRODUCTS .22. THE ABSOLUTE STEREOSTRUCTURE OF SWINHOLIDE-A, A POTENT CYTOTOXIC DIMERIC MACROLIDE FROM THE OKINAWAN MARINE SPONGE THEONELLA-SWINHOEI
KOBAYASHI, M
TANAKA, JI
KATORI, T
MATSUURA, M
YAMASHITA, M
KITAGAWA, I
CHEMICAL & PHARMACEUTICAL BULLETIN, 1990, 38 (09) : 2409 - 2418
[6] MARINE NATURAL-PRODUCTS .31. STRUCTURE-ACTIVITY CORRELATION OF A POTENT CYTOTOXIC DIMERIC MACROLIDE SWINHOLIDE-A, FROM THE OKINAWAN MARINE SPONGE THEONELLA-SWINHOEI, AND ITS ISOMERS
KOBAYASHI, M
KAWAZOE, K
OKAMOTO, T
SASAKI, T
KITAGAWA, I
CHEMICAL & PHARMACEUTICAL BULLETIN, 1994, 42 (01) : 19 - 26
[7] MARINE NATURAL-PRODUCTS .25. BIOLOGICALLY-ACTIVE TRIDECAPEPTIDE LACTONES FROM THE OKINAWAN MARINE SPONGE THEONELLA-SWINHOEI (THEONELLIDAE) (1) - STRUCTURE OF THEONELLAPEPTOLIDE ID
KITAGAWA, I
LEE, NK
KOBAYASHI, M
SHIBUYA, H
TETRAHEDRON, 1991, 47 (12-13) : 2169 - 2180
[8] MOLECULAR-CONFORMATION OF SWINHOLIDE-A, A POTENT CYTOTOXIC DIMERIC MACROLIDE FROM THE OKINAWAN MARINE SPONGE THEONELLA-SWINHOEI - X-RAY CRYSTAL-STRUCTURE OF ITS DIKETONE DERIVATIVE
DOI, M
ISHIDA, T
KOBAYASHI, M
KITAGAWA, I
JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (11): : 3629 - 3632
[9] MARINE NATURAL-PRODUCTS .23. 3 NEW CYTOTOXIC DIMERIC MACROLIDES, SWINHOLIDE-B AND SWINHOLIDE-C AND ISOSWINHOLIDE-A, CONGENERS OF SWINHOLIDE-A, FROM THE OKINAWAN MARINE SPONGE THEONELLA-SWINHOEI
KOBAYASHI, M
TANAKA, J
KATORI, T
KITAGAWA, I
CHEMICAL & PHARMACEUTICAL BULLETIN, 1990, 38 (11) : 2960 - 2966

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