ATP-DEPENDENT TRANSPORT FOR GLUCURONIDES IN CANALICULAR PLASMA-MEMBRANE VESICLES

被引：53
|
作者：
KOBAYASHI, K
KOMATSU, S
NISHI, T
HARA, H
HAYASHI, K
机构：
[1] The Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, 567
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 176卷 / 02期
关键词：
D O I：
10.1016/S0006-291X(05)80229-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Using rat liver canalicular plasma membrane vesicles, it has been verified that the transport of p-nitrophenyl glucuronide (NPG) across membranes is an ATP-dependent process; the apparent Km for NPG was 20 μM. S-(2,4-dinitrophenyl)-glutathione (DNP-SG) inhibited NPG uptake dose-dependently, and NPG or testosterone glucuronide did ATPdependent DNP-SG uptake similarly. These results suggest that transport of glucuronide is mediated by an ATP-dependent glutathione S-conjugate carrier. © 1991 Academic Press, Inc.
引用
收藏
页码：622 / 626
页数：5
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