Biological Characterization of Cynara cardunculus L. Methanolic Extracts: Antioxidant, Anti-proliferative, Anti-migratory and Anti-angiogenic Activities

被引:40
|
作者
Velez, Zelia [1 ,2 ]
Campinho, Marco A. [1 ]
Guerra, Angela R. [2 ,3 ]
Garcia, Laura [2 ]
Ramos, Patricia [2 ,3 ]
Guerreiro, Olinda [2 ,3 ]
Felicio, Laura [2 ]
Schmitt, Fernando [4 ,5 ]
Duarte, Maria [2 ,3 ]
机构
[1] Univ Algarve, Ctr Marine Sci CCMAR, Campus Gambelas, P-8005139 Faro, Portugal
[2] Inst Politecn Beja IPBeja, Ctr Biotecnol Agr & Agroalimentar Baixo Alentejo, P-7801908 Beja, Portugal
[3] Univ Aveiro, Ctr Res Ceram & Composite Mat CICECO, P-3810193 Aveiro, Portugal
[4] Univ Porto, IPATIMUP, Inst Mol Pathol & Immunol, P-4200465 Porto, Portugal
[5] Univ Porto, Med Fac, Dept Pathol & Oncol, P-4200319 Porto, Portugal
来源
AGRICULTURE-BASEL | 2012年 / 2卷 / 04期
关键词
Cynara cardunculus; phenols; antioxidant; antitumor; breast cancer;
D O I
10.3390/agriculture2040472
中图分类号
S3 [农学(农艺学)];
学科分类号
0901 ;
摘要
Cynara cardunculus (Cc) is a multipurpose species; beyond its use in southwestern European cuisine, it is also used for the production of solid biofuel, seed oil, biodiesel, paper pulp and cheese, as well as animal feed. In addition, Cc has a long tradition of use in folk medicine as a diuretic and liver protector. The value of this species as a source of bioactive compounds is known; however, pharmacological use would further increase its cultivation. The main goal of the current work was to evaluate the potential of Cc as source of anti-carcinogenic phytochemicals. Different methanolic extracts obtained from wild and cultivated plants were tested for antioxidant activity and effect on breast tumor cell viability. The most effective extract, both as antioxidant and inhibition of tumor cell viability, was tested for effects on angiogenesis and tumor cell migration capacity. All the extracts tested had high antioxidant activity; however, only green leaves and dry head extracts exhibit anti-proliferative activity. Green cultivated leaves (GCL) were the most effective extract both as antioxidant and inhibiting the proliferation of tumor cells; it is equally active inhibiting tumor cell migration and in vivo angiogenesis. GCL extract is an effective inhibitor of several key points in tumor development and thus a promising source of anti-carcinogenic phytochemicals.
引用
收藏
页码:472 / 492
页数:21
相关论文
共 50 条
  • [1] Anti Tumor Activity of Salvia officinalis is Due to Its Anti-Angiogenic, Anti-Migratory and Anti-Proliferative Effects
    Keshavarz, Maryam
    Bidmeshkipour, Ali
    Mostafaie, Ali
    Mansouri, Kamran
    Mohammadi-Motlagh, Hamid-Reza
    [J]. YAKHTEH, 2011, 12 (04): : 477 - 482
  • [2] Fusarielin A as an anti-angiogenic and anti-proliferative agent: Basic biological characterization
    Fujimoto, Haruka
    Aoyama, Hiroshi
    Noguchi-Yachide, Tomomi
    Hashimoto, Yuichi
    Kobayashi, Hisayoshi
    [J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2008, 56 (03) : 298 - 304
  • [3] Anti-proliferative and Anti-migratory Activities of Diphyllin on Human Colorectal Cancer Cells
    Puli, Sagar
    Raveendran, Ramasamy
    [J]. JOURNAL OF YOUNG PHARMACISTS, 2022, 14 (02) : 198 - 202
  • [4] Methanolic extract of Euchelus asper exhibits in-ovo anti-angiogenic and in vitro anti-proliferative activities
    Agrawal, Sweta
    Chaugule, Sachin
    More, Shashank
    Rane, Gargi
    Indap, Madhavi
    [J]. BIOLOGICAL RESEARCH, 2017, 50
  • [5] Methanolic extract of Euchelus asper exhibits in-ovo anti-angiogenic and in vitro anti-proliferative activities
    Sweta Agrawal
    Sachin Chaugule
    Shashank More
    Gargi Rane
    Madhavi Indap
    [J]. Biological Research, 50
  • [6] In vitro anti-proliferative and anti-angiogenic activities of thalidomide dithiocarbamate analogs
    El-Aarag, Bishoy Y. A.
    Kasai, Tomonari
    Zahran, Magdy A. H.
    Zakhary, Nadia I.
    Shigehiro, Tsukasa
    Sekhar, Sreeja C.
    Agwa, Hussein S.
    Mizutani, Akifumi
    Murakami, Hiroshi
    Kakuta, Hiroki
    Seno, Masaharu
    [J]. INTERNATIONAL IMMUNOPHARMACOLOGY, 2014, 21 (02) : 283 - 292
  • [7] Anti-Proliferative and Anti-Migratory Activities of Hispidulin on Human Melanoma A2058 Cells
    Chang, Chi-Jen
    Hung, Yen-Ling
    Chen, Ting-Chen
    Li, Hsin-Ju
    Lo, Yuan-Hsin
    Wu, Nan-Lin
    Chang, Der-Chen
    Hung, Chi-Feng
    [J]. BIOMOLECULES, 2021, 11 (07)
  • [8] Implants composed of digoxin and poly(ε-caprolactone): development, characterization, anti-proliferative and anti-angiogenic activities
    Rodrigues, F. F.
    Braz, W. R.
    Perasoli, F. B.
    Ferreira, L. G. R.
    Barbosa, L. A. De O.
    Da Silva, G. R.
    [J]. PHARMAZIE, 2017, 72 (07): : 383 - 388
  • [9] Design, synthesis and characterization of potent microtubule inhibitors with dual anti-proliferative and anti-angiogenic activities
    Zhang, Huijun
    Fang, Xiong
    Meng, Qian
    Mao, Yujia
    Xu, Yan
    Fan, Tingting
    An, Jing
    Huang, Ziwei
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 157 : 380 - 396
  • [10] Anti-angiogenic and anti-proliferative thalidomide analogs.
    Hu, ZG
    Zink, J
    Zili, X
    Shi, JD
    Li, PK
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2002, 224 : U21 - U21