DETECTION OF EPSTEIN-BARR-VIRUS IN REED-STERNBERG CELLS OF HODGKINS-DISEASE ARISING IN CHILDREN

被引：8
|
作者：
COATES, PJ [1 ]
DARDENNE, AJ [1 ]
SLAVIN, G [1 ]
KINGSTON, JE [1 ]
MALPAS, JS [1 ]
机构：
[1] ST BARTHOLOMEWS HOSP, ICRF, DEPT PAEDIAT ONCOL, LONDON EC1A 7BE, ENGLAND
来源：
MEDICAL AND PEDIATRIC ONCOLOGY | 1993年 / 21卷 / 01期
关键词：
EBV; INSITU HYBRIDIZATION; DIGOXIGENIN;
D O I：
10.1002/mpo.2950210105
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Nonisotopic in situ hybridization has been used to investigate the role of Epstein-Barr virus (EBV) in the aetiology of pediatric Hodgkin's disease. Sections from 24 cases arising in children under the age of 15 years were hybridised with digoxigenin-labelled probes for both EBV and cytomegalovirus, and reactive sites were identified by a sensitive three-layer immunoperoxidase technique. EBV was identified in Reed-Sternberg and mononuclear Hodgkin's cells in five samples (21%). No samples were positive when the cytomegalovirus probe was employed. The specific identification of EBV in the malignant cells of Hodgkin's disease arising in children lends further support for a role of EBV in the aetiology of this disorder.
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收藏
页码：19 / 23
页数：5
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