REPRESSED EXPRESSION OF THE HER-2/C-ERBB-2 PROTOONCOGENE BY THE ADENOVIRUS E1A GENE-PRODUCTS

被引：0
|
作者：
YAN, DH
CHANG, LS
HUNG, MC
机构：
[1] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT TUMOR BIOL,BOX 79,1515 HOLCOMBE BLVD,HOUSTON,TX 77030
[2] PRINCETON UNIV,HOWARD HUGHES MED INST,DEPT BIOL,PRINCETON,NJ 08544
来源：
ONCOGENE | 1991年 / 6卷 / 02期
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The E3 region of adenovirus induces down-regulation of epidermal growth factor receptor (EGFR) through endocytosis. Here we report that an EGFR-related protein, the HER-2/c-erbB-2 gene product, p185, is also down-regulated by adenovirus, but via a different mechanism. We found that the adenovirus E1a gene is responsible for the repression of HER-2/c-erbB-2 at the RNA level.
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页码：343 / 345
页数：3
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