CHROMOSOMAL LOCALIZATION OF 7 PAX GENES AND CLONING OF A NOVEL FAMILY MEMBER, PAX-9

被引：200
|
作者：
STAPLETON, P [1 ]
WEITH, A [1 ]
URBANEK, P [1 ]
KOZMIK, Z [1 ]
BUSSLINGER, M [1 ]
机构：
[1] RES INST MOLEC,PATHOL DR BOHR GASSE 7,A-1030 VIENNA,AUSTRIA
来源：
NATURE GENETICS | 1993年 / 3卷 / 04期
关键词：
D O I：
10.1038/ng0493-292
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
In the human paired box-containing (PAX) gene family, only two members, PAX-3 and PAX-6, which are associated with Waardenburg's syndrome and aniridia, respectively have been mapped to human chromosomes. We have now isolated cosmids for six additional human PAX genes (PAX-1,-2,-5,-7,-8,-9) and a polymerase chain reaction fragment for PAX-4. PAX-9 is a novel family member which is closely related in its paired domain to PAX-1. The chromosomal location of all cloned PAX genes was determined by analysis of somatic cell hybrids and (except PAX-4) by fluorescence in situ hybridization to metaphase chromosomes. PAX-1 and PAX-7 map to chromosomal regions containing previously assigned disease loci.
引用
收藏
页码：292 / 298
页数：7
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