SYNTHESIS AND CELL-ADHESION PROPERTIES OF CYCLO(-ARG-GLY-ASP-SER-LYS-), A CONSTRAINED ANALOG OF THE ACTIVE DOMAIN OF FIBRONECTIN

被引：6
|
作者：
DAVIES, JS [1 ]
ENJALBAL, C [1 ]
WISE, CJ [1 ]
WEBB, SE [1 ]
JONES, GE [1 ]
机构：
[1] UNIV LONDON KINGS COLL,RANDALL INST,LONDON WC2B 5RL,ENGLAND
来源：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 14期
关键词：
D O I：
10.1039/p19940002011
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Details of the synthesis of the protected pentapeptide linear precursor on a resin with an acid-labile linker, and its subsequent cyclisation to cyclo(-Arg-Gly-Asp-Ser-Lys-) are presented. The cyclopentapeptide, which is known to exist in solution in a beta- and gamma-turn conformation, shows specific differences in its effect on adhesion and cell spreading for fibroblast 3T3 and macrophage Bac 1 cells.
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收藏
页码：2011 / 2015
页数：5
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