HORMONAL MECHANISMS OF THROMBOCYTOPOIESIS REGULATION

The role played by the adrenals and the insular apparatus of the pancreas was studied in experiments on dogs. It was found that prednisolone and adrenaline enhance thrombocytopoiesis while unilateral adrenalectomy supprresses it. Bilateral adrenalectomy brought about an increase in the number and functioning of thrombocytes along with a drastic reduction in megakaryocyte counts. Pancreatectomy and alloxane diabetes were associated with sharp thrombocytopenia with decreased daily thrombocytopoiesis and megakaryocyte counts. Administration of insulin to intact dogs was attended with an increase in megakaryocyte counts and in the adhesive and aggregation function of thrombocytes. Insulin was found to stimulate thrombocytopoiesis under medicamentous thrombocytopenia.