PRODUCTION AND CHARACTERIZATION OF A MURINE HUMAN CHIMERIC ANTIIDIOTYPE ANTIBODY THAT MIMICS GANGLIOSIDE

被引：0
|
作者：
HASTINGS, A
MORRISON, SL
KANDA, S
SAXTON, RF
IRIE, RF
机构：
[1] UNIV CALIF LOS ANGELES, SCH MED, DEPT SURG ONCOL, LOS ANGELES, CA 90024 USA
[2] UNIV CALIF LOS ANGELES, JONSSON COMPREHENS CANC CTR, INST MOLEC BIOL, LOS ANGELES, CA 90024 USA
来源：
CANCER RESEARCH | 1992年 / 52卷 / 07期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The V(L) and V(H) from a murine anti-idiotypic antibody that mimics ganglioside have been cloned, sequenced, and expressed as a chimeric mouse/human IgG1 antibody. The chimeric antibody retained a binding specificity indistinguishable from the original murine antibody. The V(H) was a member of V gam 3.8 family. The sequences are discussed in terms of ways in which proteins may mimic ganglioside epitopes.
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页码：1681 / 1686
页数：6
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