THE ACCUMULATION OF NOVOBIOCIN BY ESCHERICHIA-COLI AND STAPHYLOCOCCUS-AUREUS

被引：3
|
作者：
BARRETTBEE, K
PINDER, P
机构：
[1] Infection Research Department, Zeneca Pharmaceuticals, Macclesfield, Cheshire, SK10 4TG, Alder ley Park
来源：
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1994年 / 33卷 / 06期
关键词：
D O I：
10.1093/jac/33.6.1165
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The accumulation of novobiocin by Escherichia coli was shown to be a non-saturable process. Inhibitors or uncouplers of respiration had no effect on accumulation in cells grown in Isosensitest broth, whereas, bacteria grown in nutrient broth demonstrated an energy-dependent efflux mechanism. In contrast, accumulation of novobiocin by Staphylococcus aureus was found to have a Km of 74 μM and uncouplers and inhibitors of respiration reduced the accumulation suggesting that in S. aureus novobiocin is transported actively. © 1994 The British Society for Antimicrobial Chemotherapy.
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页码：1165 / 1171
页数：7
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