TWICE-DAILY DOSING OF ERYTHROMYCIN ACISTRATE IN THE TREATMENT OF ACUTE BRONCHITIS AND PNEUMONIA

被引:0
|
作者
WIESNER, B
WILENROSENQVIST, G
LEHTONEN, L
机构
[1] ZENT KLIN BAD BERKA,BAD BERKA,GERMANY
[2] ORION PHARMACEUT CO,RES CTR,ESPOO,FINLAND
来源
ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH | 1993年 / 43-2卷 / 09期
关键词
ANTIBACTERIALS; CAS-96128-89-1; DOXYCYCLINE; ERASIS(R); ERYTHROMYCIN ACISTRATE; CLINICAL STUDIES;
D O I
暂无
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Erythromycin acistrate (Erasis(R), CAS 96128-89-1) is a 2'-acetyl ester prodrug of erythromycin. Due to prolonged half-life it is more suitable for twice daily dosing than the conventional erythromycin preparations. In the present double-blind trial, totally 297 ambulatory patients with respiratory tract infections were treated either with erythromycin acistrate 800 mg daily or doxycycline 100 mg daily. 243 of the included patients had bronchitis, 15 patients bronchitis and other respiratory tract symptoms, 25 patients pneumonia and 14 other respiratory tract infections. The duration of treatment varied from 7 to 14 days depending on the severity of infection. The efficacy of both treatments was very good 96.6 % of the patients treated with erythromycin acistrate and 97.2 % of the patients treated with doxycycline improved. The efficacy of erythromycin acistrate in the treatment of bronchitis and pneumonia was 96.7 and 100 %, respectively. Only 5 of the totally 148 patients failed. Side effects (mainly gastrointestinal symptoms) were seen in 12.1 % of the patients (20 patients in the erythromycin acistrate group and 16 patients in the doxycycline group). The results show that erythromycin acistrate dosed twice daily is as effective as doxycycline and well tolerated in the treatment of lower respiratory tract infections.
引用
收藏
页码:1014 / 1017
页数:4
相关论文
共 50 条
  • [1] TWICE-DAILY PARENTERAL CEPHAPIRIN DOSING IN INFANTS WITH PNEUMONIA
    CEDRATO, A
    LARGUIA, A
    CLINICAL MEDICINE, 1973, 80 (10) : 27 - 29
  • [2] Efficacy and tolerability of twice-daily ciprofloxacin 750mg in the treatment of patients with acute exacerbations of chronic bronchitis and pneumonia
    Pryka, R
    Kowalsky, S
    Haverstock, D
    CLINICAL THERAPEUTICS, 1998, 20 (01) : 141 - 155
  • [3] LITHIUM TREATMENT - A COMPARISON OF ONCE-DAILY AND TWICE-DAILY DOSING
    ABRAHAM, G
    DELVA, N
    WALDRON, J
    LAWSON, JS
    OWEN, J
    ACTA PSYCHIATRICA SCANDINAVICA, 1992, 85 (01) : 65 - 69
  • [4] TWICE-DAILY DOSING OF VERAPAMIL IN HYPERTENSION
    JOKINEN, A
    SUNDBERG, S
    OTTOILA, P
    HEIKKILA, J
    GORDIN, A
    CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, 1985, 38 (06): : 966 - 973
  • [5] TWICE-DAILY DOSING OF VALPROATE WITH DIVALPROEX
    WILDER, BJ
    KARAS, BJ
    HAMMOND, EJ
    PERCHALSKI, RJ
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 1983, 34 (04) : 501 - 504
  • [6] EFFECTIVENESS OF TWICE-DAILY CEPHALEXIN IN THE TREATMENT OF PNEUMOCOCCAL PNEUMONIA
    MAGUIRE, GP
    LEE, M
    LYONS, HA
    CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, 1986, 39 (04): : 549 - 553
  • [7] Efficacy and safety of once-daily and twice-daily clarithromycin formulations in the treatment of acute exacerbations of chronic bronchitis
    Vetter, N
    Argryopoulou-Pataka, P
    Droszcz, W
    Estruch-Riba, R
    Thomas, P
    MacLeod, CM
    ADVANCES IN THERAPY, 1999, 16 (01) : 13 - 21
  • [8] TWICE-DAILY SUCRALFATE DOSING TO HEAL ACUTE DUODENAL-ULCER
    SCHUBERT, T
    AMERICAN JOURNAL OF MEDICINE, 1989, 86 (6A): : 108 - 112
  • [9] EFFICACY AND TOLERANCE OF ERYTHROMYCIN ACISTRATE IN THE TREATMENT OF ACUTE EXACERBATIONS OF CHRONIC-BRONCHITIS IN THE ELDERLY
    FORSEN, KO
    WIKBERG, R
    LEHTONEN, L
    CHEMOTHERAPY, 1993, 39 (06) : 443 - 452
  • [10] ANALGESIC EFFICACY IN OSTEOARTHRITIS - TWICE-DAILY DOSING
    SKOSEY, JL
    AMERICAN JOURNAL OF MEDICINE, 1986, 80 (3A): : 110 - 111