HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF DIASTEREOMERS AND ENANTIOMERS OF PYRROLOISOQUINOLINE ANTIDEPRESSANTS

被引：2
|
作者：
SHAH, RD [1 ]
MARYANOFF, CA [1 ]
机构：
[1] RW JOHNSON PHARMACEUT RES INST,DEPT CHEM DEV,SPRING HOUSE,PA 19477
来源：
JOURNAL OF CHROMATOGRAPHY | 1991年 / 588卷 / 1-2期
关键词：
D O I：
10.1016/0021-9673(91)85045-H
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
To determine the diastereomeric and enantiomeric purity of different sets of isomers of pyrroloisoquinoline compounds in a reaction mixture, two general direct high-performance liquid chromatographic (HPLC) methods were developed: a reversed-phase HPLC method for diastereomers and a normal-phase HPLC method for enantiomers. These methods allowed us to monitor the course of reactions; changes in reaction variables were made until optimized conditions were identified to provide enantiomerically pure products.
引用
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页码：348 / 351
页数：4
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