A CHIRAL CYANOHYDRIN PHOSPHATE FOR CARBONYL UMPOLUNG - STEREOSELECTIVE SYNTHESIS OF TERTIARY CYANOHYDRINS

被引：26

作者：

SCHRADER, T

机构：

[1] Institut für Organische Chemie, Makromolekulare Chemie, Universität Düsseldorf, D-40225

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 08期

关键词：

ASYMMETRIC SYNTHESES; CYANOHYDRINS; DRUGS; UMPOLUNG;

D O I：

10.1002/anie.199509171

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

High asymmetric induction is achieved in the diastereoselective alkylation of cyanohydrin carbanion 1 (de = 82–94%). The synthesis of optically active tertiary cyanohydrins demonstrates how P‐chiral auxiliaries temporarily linked to the substrate through heteroatoms can be used in asymmetric synthesis. (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：917 / 919

页数：3

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