CARBONIC-ANHYDRASE ACTIVATORS .13. ARYL-ETHYLAMINES AND HETARYL-ETHYLAMINES ARE POTENT NONCOMPETITIVE ACTIVATORS OF ESTERASIC ACTIVITY OF ISOZYME-II

被引：0
|
作者：
COLTAU, M
PUSCAS, I
SUPURAN, CT
机构：
[1] UNIV BUCHAREST,DETP CHEM,BD CARO I REPUBL 13,R-70346 BUCHAREST,ROMANIA
[2] ROUMANIAN MED ACAD,CTR RES MED ASSISTANCE,R-4775 SIMLEU SILVANIEI,ROMANIA
来源：
REVUE ROUMAINE DE CHIMIE | 1994年 / 39卷 / 04期
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D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Typical carbonic anhydrase (CA) activators for the CO2 hydration reaction (such as histamine, adrenaline, noradrenaline or isoprotenerol) were found to activate the enzyme for 4-nitrophenylacetate hydrolysis reaction too. A kinetic study was done using bovine CA II, both for CO2 hydration reaction in the presence of these activators (using a stopped-flow technique), as well as for the hydrolysis of 4-nitro-phenylacetate (by a spectrophotometric method). The kinetic data indicate a non-competitive type of interaction between enzyme, substrates and activators.
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页码：457 / 462
页数：6
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