Based on a three-year study on the optimization of nitrogen fertilizing of winter wheat cultivated using no-till technology in dark-chestnut soils in the arid zone of the Stavropol Territory, it has been established that it is economically feasible to use a solution of urea-ammonia mixture in a dose of 87 kg of active ingredient N by the method of intra soil injection using Multiinjector and Duportliquilazer aggregates with the formation of the maximum crop productivity in the experiment at the level of 5.3-5.34 t/ha, and characterized by the highest relative economic efficiency of 73.5%. The use of nitrogen supplements increased the productivity and structure of the crop of winter wheat. The considered dose of nitrogen fertilizers in a dose of 87 kg/ha contributed to an increase in the protein content of grain by 1.7-3.5%, fulfillment of grain (nature) by 66-81 units, grain size or 1000 grain by 5.8-6.9 city, the amount of raw gluten by 2.9-7.6%, the grain obtained in the studied variants corresponded to the 1st quality group (44-77 GSM units). The formation of the highest crop productivity (5.3 5.34 t/ha) was promoted by the use of nitrogen fertilizers in early-spring top dressing using a urea-ammonia mixture by soil subsoil injection, which exceeded t he values of the options with the surface application of nitrogen feeds in the form of ammonium nitrate and CAS solution on 0.8-0.18 t/ha. The best indicators of economic efficiency are characterized by the variant with the intrasoil use of a solution of a urea-ammonia mixture in a single dose of 87 kg of active substance/ha or 250 kg/ha in physical weight using Multiinjector unit, the level of profitability was 73.5%