Successful treatment of primary advanced gastric plasmacytoma using a combination of surgical resection and chemotherapy with bortezomib: A case report

被引:7
|
作者
Fukuhara, Sotaro [1 ]
Tazawa, Hirofumi [1 ]
Okanobu, Hideharu [2 ]
Kida, Michiko [3 ]
Kido, Miki [3 ]
Takafuta, Toshiro [3 ]
Nishida, Toshihiro [4 ]
Ohdan, Hideki [5 ]
Sakimoto, Hideto [1 ,5 ]
机构
[1] Chugoku Rosai Hosp, Dept Surg, 1-5-1 Tagaya, Kure, Hiroshima 7370193, Japan
[2] Chugoku Rosai Hosp, Dept Internal Med, 1-5-1 Tagaya, Kure, Hiroshima 7370193, Japan
[3] Natl Hosp Org, Kure Med Ctr, Dept Hematol, 3-1 Aoyamatyo, Kure, Hiroshima 7370023, Japan
[4] Chugoku Rosai Hosp, Dept Diagnost Pathol, 1-5-1 Tagaya, Kure, Hiroshima 7370193, Japan
[5] Hiroshima Univ, Inst Biomed & Hlth Sci, Dept Gastroenterol & Transplant Surg, Appl Life Sci,Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan
关键词
Plasmacytoma; Stomach; Surgical resection; Chemotherapy;
D O I
10.1016/j.ijscr.2016.08.041
中图分类号
R61 [外科手术学];
学科分类号
摘要
INTRODUCTION: Extramedullary plasmacytoma (EMP) is a plasma cell neoplasm that presents as a solitary tumor. EMP in the gastrointestinal organs are extremely uncommon. PRESENTATION OF CASE: A 36-year-old man was admitted to our hospital with advanced anemia. He had no specific medical history. Gastroendoscopic findings showed an 8.0-cm submucosal tumor with ulcer on the greater curvature of the gastric body. Fine-needle aspiration was performed, and the pathologic diagnosis of the submucosal tumor was a plasmacytoma. Therefore, the patient was diagnosed with gastric plasmacytoma. A total gastrectomy was performed with lymphadenectomy. The result of intraoperative peritoneal lavage cytology was positive. Histological examination revealed serosa-exposed plasmacytoma of the stomach with lymph nodes metastasis. Additionaly the patient received a three-drug chemotherapy regimen (bortezomib, cyclophosphamide, and dexamethasone [VCD]) from 3 weeks after the operation. After 4 cycles of chemotherapy, the patient received autologous peripheral blood stem-cell transplantation (auto-PBSCT). Eighteen months after diagnosis, the patient is in complete remission with no evidence of local relapse or evolution to multiple myeloma. CONCLUSIONS: This is the first reported case of advanced gastric plasmacytoma using adjuvant chemotherapy involving bortezomib and auto-PBSCT after the resection, and the patient has maintained a good course over a year. This protocol could be a new way to treat these tumors. (C) 2016 The Authors. Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd.
引用
收藏
页码:133 / 136
页数:4
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