We describe the documented link between substance use disorders and severe mental disorders; population that suffers and the characteristics of its heterogeneity (type and severity of the disorder, skills for coping, psychosocial support available and other factors involved). We review the recommendations of the National Project of Evidence Based Practice to encourage its use in organizations that provide management against addictions in Mexico, as unstructured groups, whose schemes approach reduced not assume yet the therapeutic strategies combined psychotherapeutic interventions, social and pharmacological, which aggravates co-morbid disorders, representing a serious challenge to any health care system. Such conditions in most of the services related, not even contemplate the management of this interaction, limiting most of the patients access to simultaneous handling of their disorders. It describes the goals of rehabilitation based interventions to promote to improve personal skills and appropriate use of support systems. It is intended to facilitate the affected its confrontation with the pathology to overcome his disability, the goal of achieving individual process of generating hope and autonomy. It concludes by noting some actions which together represent the management of comorbidity in favour of a custom process, at the hands of qualified personnel prepared ad hoc, and guided by programs that use sites and systems to promote abstinence, with support from psychoeducation programs and family system.