EXPRESSION OF ADHESION MOLECULES NCAM, L1 AND OF THE HNK1 EPITROPE BY MEDULLOBLASTOMAS

被引：0

作者：

FIGARELLABRANGER, D ^{[1
]}

DURBEC, P ^{[1
]}

BIANCO, N ^{[1
]}

GAMBARELLI, D ^{[1
]}

PELLISSIER, JF ^{[1
]}

ROUGON, G ^{[1
]}

机构：

[1] FAC SCI LUMINY, CNRS, URA 179, F-13288 MARSEILLE 9, FRANCE

来源：

REVUE NEUROLOGIQUE | 1992年 / 148卷 / 6-7期

关键词：

D O I：

暂无

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Twelve medulloblastomas were screened for their expression of adhesion molecules L1, N.CAM isoforms and HNK1 epitope by Western blotting and immunohistochemistry. Highly sialylated N.CAM isoforms were distinguished from total N.CAMs by using a monoclonal antibody (anti-MenB) specifically recognizing high polymers of 2-8 linked neuraminic acid. All tumors expressed HNK1 epitope, N.CAM and its highly sialylated isoforms on their surface membrane. L1 adhesion molecule was detected by immunohistochemistry in only one medulloblastoma. This spectrum of expression of cell surface adhesion molecules distinguishes medulloblastomas from other primitive neuroectodermal tumors. Medulloblastomas share some immunological features with post-mitotic cells forming the external granular layer of the cerebellum. Western blotting analysis of cerebrospinal fluid (CSF) samples with anti-MenB antibody enabled us to detect highly sialylated N.CAM in some samples. The presence of this antigen in CSF appears to correlate with meningeal spreading of medulloblastomas and could help monitoring chemotherapeutic treatment.

引用

页码：417 / 422

页数：6

共 50 条

[1] STRUCTURE AND FUNCTION OF THE NEURAL CELL-ADHESION MOLECULES NCAM AND L1
NYBROE, O
BOCK, E
MOLECULAR ASPECTS OF DEVELOPMENT AND AGING OF THE NERVOUS SYSTEM, 1989, 265 : 185 - 196
[2] Chronic stress induces opposite changes in the mRNA expression of the cell adhesion molecules NCAM and L1
Venero, C
Tilling, T
Hermans-Borgmeyer, I
Schmidt, R
Schachner, M
Sandi, C
NEUROSCIENCE, 2002, 115 (04) : 1211 - 1219
[3] EXPRESSION OF THE CELL-ADHESION MOLECULES NCAM AND L1 IN TUMOR-CELLS WITH DIFFERING METASTATIC POTENTIAL
LINNEMANN, D
ANDERSSON, AM
RAZ, A
LAERUM, OD
BOCK, E
JOURNAL OF CELLULAR BIOCHEMISTRY, 1987, : 109 - 109
[4] L1 and NCAM adhesion molecules as signaling coreceptors in neuronal migration and process outgrowth
Schmid, Ralf S.
Maness, Patricia F.
CURRENT OPINION IN NEUROBIOLOGY, 2008, 18 (03) : 245 - 250
[5] Molecular Mechanisms of L1 and NCAM Adhesion Molecules in Synaptic Pruning, Plasticity, and Stabilization
Duncan, Bryce W.
Murphy, Kelsey E.
Maness, Patricia F.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9
[6] HIPPOCAMPAL LONG-TERM POTENTIATION AND PLEURAL CELL-ADHESION MOLECULES L1 AND NCAM
LUTHI, A
LAURENT, JP
FIGUROV, A
MULLER, D
SCHACHNER, M
NATURE, 1994, 372 (6508) : 777 - 779
[7] The L1/NCAM cis-interaction influences the association of L1 but not of NCAM with the cytoskeleton
Langenfeld-Oster, B
Müller, C
Schmitz, B
EUROPEAN JOURNAL OF NEUROSCIENCE, 2000, 12 : 181 - 181
[8] Expression, crystallization and preliminary X-ray analysis of extracellular modules of the neural cell-adhesion molecules NCAM and L1
Kulahin, N
Kasper, CBB
Gajhede, M
Berezin, V
Bock, E
Kastrup, JS
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2004, 60 : 591 - 593
[9] The neural cell adhesion molecules L1 and NCAM-180 act in different steps of neurite outgrowth
Takei, K
Chan, TA
Wang, FS
Deng, HY
Rutishauser, U
Jay, DG
JOURNAL OF NEUROSCIENCE, 1999, 19 (21): : 9469 - 9479
[10] EVIDENCE FOR CARBOHYDRATE-MEDIATED INTERACTIONS BETWEEN THE NEURAL-CELL-ADHESION MOLECULES NCAM AND L1
FEIZI, T
TRENDS IN BIOCHEMICAL SCIENCES, 1994, 19 (06) : 233 - 234

← 1 2 3 4 5 →