CLONING, CHARACTERIZATION, AND EXPRESSION OF ANIMAL TOXIN GENES FOR VACCINE DEVELOPMENT

被引：14
|
作者：
SMITH, LA
机构：
[1] Department of Toxinology Pathology Division, U.S. Army Medical Research Institute of Infectious Diseases, Frederick
来源：
JOURNAL OF TOXICOLOGY-TOXIN REVIEWS | 1990年 / 9卷 / 02期
关键词：
D O I：
10.3109/15569549009033116
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Gene libraries have been constructed from the messenger ribonucleic acid (mRNA) isolated from venom glands of different poisonous animals such as snakes, scorpions, and snails. The gene banks thus created contain recombinant clones harboring DNA sequences encoding toxins with various pharmacological activities, ranging from myonecrosis-inducing to those affecting neuronal transmission. A number of these clones have been isolated and characterized, and gene expression has been attempted with limited success in Escherichia coli, baculovirus, and in two mammalian cell expression systems by using either cDNAs or synthetically-constructed genes. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
引用
收藏
页码：243 / 283
页数：41
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