FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF FAST DISSOLVING TABLETS OF RAMIPRIL SOLID DISPERSION

Ramipril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor which is metabolized to Ramiprilat in the liver and, to a lesser extent, kidneys. The poor solubility and wett ability of Ramipril leads to poor dissolution and variations in bioavailability. Solid dispersion of Ramipril was prepared using Hydroxy propyl beta-cyclodextrin to improve water solubility. Prepared solid dispersion was shown improved solubility in water of 97.5 mu g/ml. Fast dissolving tablets of Ramipril solid dispersion was prepared and evaluated for various tablet properties. Formulation (F6) was shown excellent in vitro disintegration time 100 seconds, wetting time 65.45 seconds and more than 90% drug release in 30 minutes as compared to other formulation. Prepared formulation may improve bioavailability and fast onset of action.