Comparative Study on Efficacy of 6% Hydroxyethyl Starch 130/0.42, 4% Succinylated Gelatin and Lactated Ringer Solution as a Pre-operative Fluid Replacement for Prevention of Hypotension Following Sub-arachnoid Block

Introduction: Spinal anesthesia is most commonly performed and most popular anesthetic technique. In contrast to crystalloid solutions, preloading with colloid solutions prior to spinal injection has consistently maintained blood pressure and volume expansion. Aims and Objectives: The aim of this study was to compare the efficacy of 6% hydroxyethyl Starch 130/0.42, 4% succinylated gelatin and lactated ringer as a pre-operative volume replacement in prevention of hypotension following subarachnoid block and to observe any side effects. Methods: This study conducted on 60 patients belonging to ASA Grade I and II, of either sex in the age range of 20-60 years undergoing subarachnoid block for elective lower abdominal and gynecological surgeries of moderate duration. Results: 6% hydroxyethyl starch and 4% succinylated gelatin could be extremely useful and effective for preloading before spinal anesthesia as compared to ringer lactate to prevent hypotension following subarachnoid block and there is no significant side effect observed. Conclusion: We can safely conclude colloids are required in lesser quantity for volume replacement and provide longer duration of plasma volume expansion, thus they have better hemodynamic profile as compared to ringer lactate, which though less expensive than colloids, is required in more quantity to restore intravascular volume.