PACT WITH THE DEVIL: ALEMTUZUMAB THERAPY, IMMUNE SUPPRESSION AND INFECTIOUS COMPLICATIONS IN CHRONIC LYMPHOCYTIC LEUKEMIA

被引:0
|
作者
Antohe, I. [1 ]
Dascalescu, Angela [2 ]
Burcoveanu, Cristina [3 ]
Ghiorghiu, Doramina [3 ]
Dascalu, Alina [3 ]
Danaila, C. [2 ]
机构
[1] Univ Med & Pharm Grigore T Popa, Fac Med, Iasi, Romania
[2] Univ Med & Pharm Grigore T Popa, Fac Med, Discipline Hematol, Iasi, Romania
[3] Univ Med & Pharm Grigore T Popa, Fac Med, Reg Oncol Inst Iasi, Iasi, Romania
来源
关键词
CHRONIC LYMPHOCYTIC LEUKEMIA; ALEMTUZUMAB; IMMUNE SUPPRESSION; MYCOBACTERIUM TUBERCULOSIS; ATYPICAL INFECTION;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Infectious complications are an important cause of hospitalization in patients diagnosed with chronic lymphocytic leukemia. The pathogenesis of infection is complex, involving both disease-induced and treatment-related immune depression. During the last decade, the management of chronic lymphocytic leukemia (CLL) has been redefined by the approval of monoclonal antibody-based treatment, which resulted in improved therapeutic responses. Nonetheless, the profound lymphopenia induced by monoclonal agents was accompanied by increased incidence of infections caused by a new spectrum of opportunistic microorganisms. We report the case of a patient with hypercellular CLL who received Alemtuzumab as first line therapy and obtained a satisfactory therapeutic response, but developed subsequent atypical infectious complications.
引用
收藏
页码:92 / 95
页数:4
相关论文
共 50 条
  • [1] Infectious complications of chronic lymphocytic leukemia
    Wadhwa, PD
    Morrison, VA
    SEMINARS IN ONCOLOGY, 2006, 33 (02) : 240 - 249
  • [2] Infectious Complications in Chronic Lymphocytic Leukemia
    Nosari, Annamaria
    MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES, 2012, 4 (01)
  • [3] The infectious complications of chronic lymphocytic leukemia
    Morrison, VA
    SEMINARS IN ONCOLOGY, 1998, 25 (01) : 98 - 106
  • [4] HYPOGAMMAGLOBULINEMIA AND INFECTIOUS COMPLICATIONS IN CHRONIC LYMPHOCYTIC LEUKEMIA
    Mendes, M. J.
    Ferreira, G.
    Saturnino, H.
    Almeida, J. C.
    Araujo, L. F.
    Duarte, M.
    Ribeiro, M. L.
    HAEMATOLOGICA, 2015, 100 : 277 - 278
  • [5] Preventing Infectious Complications in Chronic Lymphocytic Leukemia
    Sun, Clare
    CLINICAL ADVANCES IN HEMATOLOGY & ONCOLOGY, 2023, 21 (12) : 676 - 677
  • [6] Diagnosis and Management of Infectious Complications in Chronic Lymphocytic Leukemia
    Musteata, Larisa
    Coman, Dana
    Musteata, Vasile
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2022, 22 : S263 - S263
  • [7] A Canadian perspective on the use of immunoglobulin therapy to reduce infectious complications in chronic lymphocytic leukemia
    Lachance, S.
    Christofides, A. L.
    Lee, J. K.
    Sehn, L. H.
    Ritchie, B. C.
    Shustik, C.
    Stewart, D. A.
    Toze, C. L.
    Haddad, E.
    Vinh, D. C.
    CURRENT ONCOLOGY, 2016, 23 (01) : 42 - 51
  • [8] Alemtuzumab in the Treatment of Chronic Lymphocytic Leukemia
    Tadeusz Robak
    BioDrugs, 2005, 19 : 9 - 22
  • [9] Alemtuzumab in the treatment of chronic lymphocytic leukemia
    Robak, T
    BIODRUGS, 2005, 19 (01) : 9 - 22
  • [10] Early prediction of outcome and response to alemtuzumab therapy in chronic lymphocytic leukemia
    Rawstron, AC
    Kennedy, B
    Moreton, P
    Dickinson, AJ
    Cullen, MJ
    Richards, SJ
    Jack, AS
    Hillmen, P
    BLOOD, 2004, 103 (06) : 2027 - 2031