Infectious complications are an important cause of hospitalization in patients diagnosed with chronic lymphocytic leukemia. The pathogenesis of infection is complex, involving both disease-induced and treatment-related immune depression. During the last decade, the management of chronic lymphocytic leukemia (CLL) has been redefined by the approval of monoclonal antibody-based treatment, which resulted in improved therapeutic responses. Nonetheless, the profound lymphopenia induced by monoclonal agents was accompanied by increased incidence of infections caused by a new spectrum of opportunistic microorganisms. We report the case of a patient with hypercellular CLL who received Alemtuzumab as first line therapy and obtained a satisfactory therapeutic response, but developed subsequent atypical infectious complications.
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Niguarda Granda Hosp, Div Ematologia, Piazza Osped Maggiore 3, I-20162 Milan, ItalyNiguarda Granda Hosp, Div Ematologia, Piazza Osped Maggiore 3, I-20162 Milan, Italy
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BC Canc Agcy, Vancouver Gen Hosp, Leukemia Bone Marrow Transplant Program BC, Vancouver, BC, Canada
Univ British Columbia, Vancouver, BC V5Z 1M9, CanadaUniv Montreal, Montreal, PQ, Canada
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Leeds Gen Infirm, HMDS, Acad Unit Haematol & Oncol, Leeds LS1 3EX, W Yorkshire, EnglandLeeds Gen Infirm, HMDS, Acad Unit Haematol & Oncol, Leeds LS1 3EX, W Yorkshire, England
Rawstron, AC
Kennedy, B
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Leeds Gen Infirm, HMDS, Acad Unit Haematol & Oncol, Leeds LS1 3EX, W Yorkshire, EnglandLeeds Gen Infirm, HMDS, Acad Unit Haematol & Oncol, Leeds LS1 3EX, W Yorkshire, England
Kennedy, B
Moreton, P
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Leeds Gen Infirm, HMDS, Acad Unit Haematol & Oncol, Leeds LS1 3EX, W Yorkshire, EnglandLeeds Gen Infirm, HMDS, Acad Unit Haematol & Oncol, Leeds LS1 3EX, W Yorkshire, England
Moreton, P
Dickinson, AJ
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Leeds Gen Infirm, HMDS, Acad Unit Haematol & Oncol, Leeds LS1 3EX, W Yorkshire, EnglandLeeds Gen Infirm, HMDS, Acad Unit Haematol & Oncol, Leeds LS1 3EX, W Yorkshire, England
Dickinson, AJ
Cullen, MJ
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Leeds Gen Infirm, HMDS, Acad Unit Haematol & Oncol, Leeds LS1 3EX, W Yorkshire, EnglandLeeds Gen Infirm, HMDS, Acad Unit Haematol & Oncol, Leeds LS1 3EX, W Yorkshire, England
Cullen, MJ
Richards, SJ
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Leeds Gen Infirm, HMDS, Acad Unit Haematol & Oncol, Leeds LS1 3EX, W Yorkshire, EnglandLeeds Gen Infirm, HMDS, Acad Unit Haematol & Oncol, Leeds LS1 3EX, W Yorkshire, England
Richards, SJ
Jack, AS
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Leeds Gen Infirm, HMDS, Acad Unit Haematol & Oncol, Leeds LS1 3EX, W Yorkshire, EnglandLeeds Gen Infirm, HMDS, Acad Unit Haematol & Oncol, Leeds LS1 3EX, W Yorkshire, England
Jack, AS
Hillmen, P
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Leeds Gen Infirm, HMDS, Acad Unit Haematol & Oncol, Leeds LS1 3EX, W Yorkshire, EnglandLeeds Gen Infirm, HMDS, Acad Unit Haematol & Oncol, Leeds LS1 3EX, W Yorkshire, England