EFFECTS OF CHLORDECONE ON ISOLATED RAT-LIVER MITOCHONDRIA

被引：16
|
作者：
MANRING, JA [1 ]
MORELAND, DE [1 ]
机构：
[1] N CAROLINA STATE UNIV, DEPT CROP SCI, PROGRAM TOXICOL, RALEIGH, NC 27650 USA
来源：
TOXICOLOGY AND APPLIED PHARMACOLOGY | 1981年 / 59卷 / 03期
关键词：
D O I：
10.1016/0041-008X(81)90301-X
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Effects of chlordecone [insecticide] on membrane integrity and respiratory behavior of isolated rat liver mitochondria (RLM) were studied. Treatment of RLM with chlordecone over a concentration range of 20-100 .mu.M produced membrane disruptions as evidenced by rapid, nonenergy-dependent swelling, permeability of inner mitochondrial membrane to exogenously supplied NADH and loss of protein. Over the range of concentrations tested, chlordecone stimulated state 4 respiration, inhibited state 3 respiration during the oxidation of glutamate and succinate.
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页码：483 / 488
页数：6
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