Effects of a 12-week aerobic exercise on markers of hypertension in men

Introduction: This study was aimed at determining the effects of a 12-week aerobic exercise program on markers of hypertension in men. Methods: The study was of a semi-experimental design featuring repeated measurements. A total of 40 men (age range = 37.9 +/- 2.68) with primary hypertension were divided into two groups, namely, the exercise group (n = 20) and the control group (n = 20) (systolic blood pressure [SBP]: 140.531 +/- 0.23, diastolic blood pressure [DBP]: 90.71 +/- 0.05). The exercise group participated in a 12-week aerobic exercise program (55% to 70% of HRmax). Blood samples were taken from both groups at the baseline and at the 4th, 8th, and 12th weeks of the training program for the assessment of adiponectin, paraoxonase-1 (PON-1), and hydrogen peroxide (H2O2) levels as the markers for investigation. A linear mixed model was also used to evaluate the association among the markers. Results: In the exercise group, exercise reduced the SBP and DBP at week 12 (P = 0.031 and 0.023, respectively), and adiponectin increased at weeks 8 and 12 (P = 0.014 and 0.001, respectively). The plasma PON-1 level showed a significant increase in all the three stages of measurement (P = 0.007, 0.004, and 0.002 at weeks 4, 8, and 12, respectively), whereas the H2O2 levels showed a significant decrease at weeks 8 and 12 (P = 0.013 and 0.011, respectively). The control group exhibited significantly decreased PON-1 (P = 0.003) and adiponectin (P = 0.025) levels but significantly increased SBP at week 12 (P = 0.032). Conclusion: The exercise-induced reduction of oxidative stress exerts a considerable effect on the reduction of blood pressure in hypertensive patients. According to our results increase in oxidative stress has the great impact on the of blood pressure.