NMDA AND KAINIC ACID RECEPTORS HAVE A COMPLEMENTARY DISTRIBUTION TO AMPA RECEPTORS IN THE HUMAN CEREBELLUM

被引:18
|
作者
JANSEN, KLR [1 ]
FAULL, RLM [1 ]
DRAGUNOW, M [1 ]
机构
[1] UNIV AUCKLAND,SCH MED,DEPT PHARMACOL,AUCKLAND,NEW ZEALAND
基金
英国医学研究理事会;
关键词
Autoradiography; Cerebellum; Human; Kainic acid receptor; N-Methyl-d-aspartate receptor; α-Amino-3-hydroxy-S-methyl-4-isoxazole propionic acid receptor;
D O I
10.1016/0006-8993(90)91783-D
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The distributions of N-methyl-d-aspartate (NMDA), α-amino-3-hydroxy-S-methyl-4-isoxazole propionic acid (AMPA) and kainic acid (KA) receptors were determined in the human cerebellum using autoradiography. In contrast to the cerebral cortex, where KA receptors have a complementary distribution to NMDA and AMPA receptors, AMPA receptors were concentrated in the cerebellar molecular layer while NMDA and KA receptors were concentrated in the granular layer. © 1990.
引用
收藏
页码:351 / 354
页数:4
相关论文
共 50 条
  • [1] KAINIC ACID DIFFERENTIATES GABA RECEPTORS FROM BENZODIAZEPINE RECEPTORS IN THE RAT CEREBELLUM
    BIGGIO, G
    CORDA, MG
    DEMONTIS, G
    STEFANINI, E
    GESSA, GL
    [J]. BRAIN RESEARCH, 1980, 193 (02) : 589 - 593
  • [2] AMPA and NMDA receptors: similarities and differences in their synaptic distribution
    Nusser, Z
    [J]. CURRENT OPINION IN NEUROBIOLOGY, 2000, 10 (03) : 337 - 341
  • [3] An immunohistochemical study of NMDA receptors in human cerebellum and hippocampus
    Koutsouraki, E. S.
    Anastasiades, J. J.
    Costa, V. G.
    Baloyannis, S. J.
    [J]. BRAIN PATHOLOGY, 2010, 20 : 15 - 15
  • [4] Tangential synaptic distribution of NMDA and AMPA receptors in rat neocortex
    Kharazia, VN
    Weinberg, RJ
    [J]. NEUROSCIENCE LETTERS, 1997, 238 (1-2) : 41 - 44
  • [5] AUTORADIOGRAPHIC LOCALIZATION OF NMDA, QUISQUALATE AND KAINIC ACID RECEPTORS IN HUMAN SPINAL-CORD
    JANSEN, KLR
    FAULL, RLM
    DRAGUNOW, M
    WALDVOGEL, H
    [J]. NEUROSCIENCE LETTERS, 1990, 108 (1-2) : 53 - 57
  • [6] Distribution of NMDA and AMPA receptors in the cerebellar cortex of rhesus macaques
    Garyfallou, VT
    Kohama, SG
    Urbanski, HF
    [J]. BRAIN RESEARCH, 1996, 716 (1-2) : 22 - 28
  • [7] Differential response of AMPA and NMDA glutamate receptors of Purkinje cells to aging of the chicken cerebellum
    Pires, Raquel S.
    Real, Caroline C.
    Folador, Thiago S.
    Tellini, Nataly R.
    Torrao, Andrea S.
    Britto, Luiz R. G.
    [J]. NEUROSCIENCE LETTERS, 2010, 478 (03) : 146 - 149
  • [8] Design of antagonists for NMDA and AMPA receptors
    Bolshakov, KV
    Kim, KH
    Potapjeva, NN
    Gmiro, VE
    Tikhonov, DB
    Usherwood, PNR
    Mellor, IR
    Magazanik, LG
    [J]. NEUROPHARMACOLOGY, 2005, 49 (02) : 144 - 155
  • [9] Desensitization of AMPA receptors and AMPA-NMDA receptor interaction: An in vivo cyclic GMP microdialysis study in rat cerebellum
    Fedele, E
    Raiteri, M
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1996, 117 (06) : 1133 - 1138
  • [10] Ionotropic Glutamate Receptors in Epilepsy: A Review Focusing on AMPA and NMDA Receptors
    Hanada, Takahisa
    [J]. BIOMOLECULES, 2020, 10 (03)