NMDA-SENSITIVE L-[H-3]GLUTAMATE BINDING IN CEREBRAL-CORTEX OF EL MICE

被引：11

作者：

OGURO, K ^{[1
]}

ITO, M ^{[1
]}

TSUDA, H ^{[1
]}

MUTOH, K ^{[1
]}

SHIRAISHI, H ^{[1
]}

SHIRASAKA, Y ^{[1
]}

MIKAWA, H ^{[1
]}

机构：

[1] KYOTO UNIV,FAC MED,DEPT PEDIAT,54 KAWAHARA CHO,SAKYO KU,KYOTO 606,JAPAN

来源：

EPILEPSY RESEARCH | 1990年 / 6卷 / 03期

关键词：

Cerebral cortex; El mice; Epilepsy; NMDA receptors;

D O I：

10.1016/0920-1211(90)90075-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

NMDA-sensitive L-[3H]glutamate binding was examined in the brains of El mice, a genetic animal model of epilepsy, and in ddY mice. In whole brain, Scatchard analysis showed that both stimulated and unstimulated El mice had significantly lower Bmax values for binding than did ddY mice. In regional studies, the binding of NMDA-sensitive l-[3H]glutamate was significantly less in the cerebral cortex of both stimulated and unstimulated El mice than in that of ddY mice. These data suggest that NMDA receptors may be involved in the genetic susceptibility of El mice to seizures. © 1990.

引用

页码：211 / 214

页数：4

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