Relapsing Cutaneous Leishmaniasis in a Patient Treated with Humira

被引：2

作者：

Otte, Erik ^{[1
]}

Christiansen, Mikael ^{[2
]}

Petersen, Eskild ^{[1
,3
]}

机构：

[1] Aarhus Univ Hosp, Dept Clin Microbiol, DK-8000 Aarhus, Denmark

[2] Aarhus Univ Hosp, Dept Rheumatol, DK-8000 Aarhus, Denmark

[3] Aarhus Univ Hosp, Dept Infect Dis, DK-8000 Aarhus, Denmark

来源：

AMERICAN JOURNAL OF INFECTIOUS DISEASES | 2015年 / 11卷 / 01期

关键词：

Cutaneous Leishmaniasis; Humira; Adalimumab; TNF-alpha Antagonist; Amphotericin B;

D O I：

10.3844/ajidsp.2015.7.10

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Leishmanias is an anthropozoonosis caused by the Leishmania protozoa. The manifestation of the disease varies depending on the type of Leishmania and the immunestatus of the patient. Tumor Necrosis Factor (TNF)-alpha antagonists were introduced in the late 1990s and have had a marked impact on rheumatic diseases. Tumor necrosis factor plays an important role in the immune systems defense against intracellular infections and the use of TNF-alpha antagonists is linked with an increased frequency of infections. We here present a case of cutaneous leishmaniasis relapse following treatment with miltefosine and amphotericin B, in a patient undergoing treatment with a TNF-alpha antagonist.

引用

页码：7 / 10

页数：4

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