DISACCHARIDASES ACTIVITY IN THE INTESTINAL-MUCOSA AFTER METHOTREXATE THERAPY

被引：1
|
作者：
DYDUCH, A
STEPLEWSKI, Z
KOEHLER, M
PISZKA, B
机构：
[1] L WARYNSKI SILESIAN MED ACAD, DEPT HYG & EPIDEMIOL, PL-41800 ZABRZE, POLAND
[2] L WARYNSKI SILESIAN MED ACAD, PEDIAT HEMATOL CLIN, PL-41800 ZABRZE, POLAND
[3] L WARYNSKI SILESIAN MED ACAD, DEPT PHYSIOL, PL-41800 ZABRZE, POLAND
来源：
PEDIATRIC HEMATOLOGY AND ONCOLOGY | 1990年 / 7卷 / 03期
关键词：
Disaccharidases; Intestinal mucosa; Methotrexate; Rats;
D O I：
10.3109/08880019009033397
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Disaccharidases activity in the intestinal mucosa samples of rats was examined after intragastric and intramuscular methotrexate therapy. Methotrexate was given on a twice a week schedule (1 mg/kg body weight). The animals were sacrificed after 2 weeks, 1 month, and 2 months of this therapy. A statistically significant but transient decrease of the lactase and maltose activity was found. The authors suggest studying the beneficial effect of low disaccharidase diet in the first period of methotrexate therapy in children treated with methotrexate. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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页码：221 / 227
页数：7
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