TRANSFORMATION OF MOUSE FIBROBLASTS TO METHOTREXATE RESISTANCE BY A RECOMBINANT PLASMID EXPRESSING A PROKARYOTIC DIHYDROFOLATE-REDUCTASE

被引：176
|
作者：
OHARE, K [1 ]
BENOIST, C [1 ]
BREATHNACH, R [1 ]
机构：
[1] FAC MED STRASBOURG,INST CHIM BIOL,INSERM,UNITE BIOL MOLEC & GENIE GENET 184,CNRS,F-67085 STRASBOURG,FRANCE
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES | 1981年 / 78卷 / 03期
关键词：
D O I：
10.1073/pnas.78.3.1527
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
引用
收藏
页码：1527 / 1531
页数：5
相关论文
共 50 条
  • [1] TRANSFORMATION OF BONE-MARROW CELLS OF MICE TO METHOTREXATE (MTX) RESISTANCE BY A RECOMBINANT PLASMID EXPRESSING A PROKARYOTIC DIHYDROFOLATE-REDUCTASE (DHFR)
    CARR, FJ
    MEDINA, WD
    BERTINO, JR
    CLINICAL RESEARCH, 1982, 30 (02): : A569 - A569
  • [2] TRANSFORMATION OF MICE WITH THE PROKARYOTIC GENE OF DIHYDROFOLATE-REDUCTASE
    TITOMIROV, AV
    APRELIKOVA, ON
    WEISMAN, BL
    TOMILIN, NV
    TSITOLOGIYA, 1985, 27 (12): : 1374 - 1379
  • [3] VECTORS CONTAINING A PROKARYOTIC DIHYDROFOLATE-REDUCTASE GENE TRANSFORM DROSOPHILA CELLS TO METHOTREXATE-RESISTANCE
    BOUROUIS, M
    JARRY, B
    EMBO JOURNAL, 1983, 2 (07): : 1099 - 1104
  • [4] REGULATION OF DIHYDROFOLATE-REDUCTASE GENE-TRANSCRIPTION IN METHOTREXATE-RESISTANT MOUSE FIBROBLASTS
    WU, JSR
    JOHNSON, LF
    JOURNAL OF CELLULAR PHYSIOLOGY, 1982, 110 (02) : 183 - 189
  • [5] METHOTREXATE BINDING TO DIHYDROFOLATE-REDUCTASE
    ROBERTS, GCK
    FEENEY, J
    BIRDSALL, B
    CHARLTON, P
    YOUNG, D
    NATURE, 1980, 286 (5770) : 309 - 309
  • [6] STRUCTURE OF DIHYDROFOLATE-REDUCTASE GENES IN METHOTREXATE-RESISTANT MOUSE LINES EXPRESSION OF MOUSE DIHYDROFOLATE-REDUCTASE IN ESCHERICHIA-COLI
    NUNBERG, JH
    KAUFMAN, RJ
    CHANG, ACY
    ERLICH, HA
    COHEN, SN
    SCHIMKE, RT
    JOURNAL OF SUPRAMOLECULAR STRUCTURE, 1979, : 69 - 69
  • [7] INDUCTION OF DIHYDROFOLATE-REDUCTASE SYNTHESIS BY POLYOMA-VIRUS IN METHOTREXATE-RESISTANT MOUSE FIBROBLASTS
    KELLEMS, RE
    MORHENN, VB
    ALT, FW
    SCHIMKE, RT
    FEDERATION PROCEEDINGS, 1978, 37 (06) : 1745 - 1745
  • [8] EXPRESSION OF MOUSE DIHYDROFOLATE-REDUCTASE GENE CONFERS METHOTREXATE RESISTANCE IN TRANSGENIC PETUNIA PLANTS
    EICHHOLTZ, DA
    ROGERS, SG
    HORSCH, RB
    KLEE, HJ
    HAYFORD, M
    HOFFMANN, NL
    BRAFORD, SB
    FINK, C
    FLICK, J
    OCONNELL, KM
    SOMATIC CELL AND MOLECULAR GENETICS, 1987, 13 (01) : 67 - 76
  • [9] A NEW FLUORESCENT DIHYDROFOLATE-REDUCTASE PROBE FOR STUDIES OF METHOTREXATE RESISTANCE
    ROSOWSKY, A
    WRIGHT, JE
    SHAPIRO, H
    BEARDSLEY, P
    LAZARUS, H
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1982, 257 (23) : 4162 - 4167
  • [10] KINETICS OF THE FORMATION AND ISOMERIZATION OF METHOTREXATE COMPLEXES OF RECOMBINANT HUMAN DIHYDROFOLATE-REDUCTASE
    APPLEMAN, JR
    PRENDERGAST, N
    DELCAMP, TJ
    FREISHEIM, JH
    BLAKLEY, RL
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1988, 263 (21) : 10304 - 10313
12345