SCREENING FOR A NEW GENERATION OF ANTHELMINTIC COMPOUNDS - INVITRO SELECTION OF THE NEMATODE CAENORHABDITIS-ELEGANS FOR IVERMECTIN RESISTANCE

被引：7
|
作者：
NOVAK, J
VANEK, Z
机构：
[1] Institute of Microbiology, Czechoslovak Academy of Sciences, Prague 4
来源：
FOLIA MICROBIOLOGICA | 1992年 / 37卷 / 03期
关键词：
D O I：
10.1007/BF02933156
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Development of resistance to ivermectin in vitro is reported for the first time. Two strains of Caenorhabditis elegans D5 and D6 able to grow on agar plates after treating with up to 3 mg ivermectin per L were selected. The parent strain N2 was extremely sensitive to ivermectin, its growth being inhibited by treatment with 0.1 - 0.2 mg IVM per L.
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页码：237 / 238
页数：2
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