THE CHALLENGE OF METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS

Staphylococcus aureus strains resistant both to methicillin and aminoglycosides emerged during the late 1970s. These have become endemic in hospitals all over the world. Outbreaks of infection and colonization may cause severe clinical and managerial problems, as therapeutic options are limited and it may be difficult to clear the carrier state. The genetics and biochemistry of these organisms are well studied, but additional antibiotics active against these strains are needed. The most urgent requirement is for rational and effective policies for control of their spread.